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| Linear Formula: | C24H37BrN2O3 |
| Molecular Weight: | 481.47 |
| MDL number: | MFCD00055069 |
Description
| Biochem/physiol Actions | Alkylating β adrenoceptor antagonist |
Properties
| form | powder |
| color | light yellow |
| mp | 70-90 °C(lit.) |
| solubility | DMF, DMSO, methanol or 10% aqueous ethanol: soluble |
| | H2O: insoluble |
| Gene Information | human ... ADRB1(153), ADRB2(154), ADRB3(155) |
| storage temp. | −20°C |
Safety
References
| reference | Pitha et al., Regeneration of β-adrenergic receptors in senescent rats: A study using an irreversible binding antagonist. Proc. Natl. Acad. Sci. U. S. A. 79, 4424, (1982) Abstract |
| | Liptak et al., Alkylating β-blockers: Activity of isomeric bromoacetyl alprenolol menthanes. J. Med. Chem. 28, 1699-1703, (1985) Abstract |
| | Minneman, et al., Interactions of putatively irreversible antagonists with β1 and β2-adrenergic receptors. Biochem. Pharmacol. 35, 857, (1986) Abstract |
